AN ONCOLYTIC VACCINIA VIRUS ENCODING HYALURONIDASE RESHAPES THE EXTRACELLULAR MATRIX TO ENHANCE CANCER CHEMOTHERAPY AND IMMUNOTHERAPY

An oncolytic vaccinia virus encoding hyaluronidase reshapes the extracellular matrix to enhance cancer chemotherapy and immunotherapy

Background The redundant Insoles extracellular matrix (ECM) within tumor microenvironment (TME) such as hyaluronic acid (HA) often impairs intratumoral dissemination of antitumor drugs.Oncolytic viruses (OVs) are being studied extensively for cancer therapy either alone or in conjunction with chemotherapy and immunotherapy.Here, we designed a novel

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Leukocytes Breach Endothelial Barriers by Insertion of Nuclear Lobes and Disassembly of Endothelial Actin Filaments

The endothelial cytoskeleton is a barrier for leukocyte transendothelial migration (TEM).Mononuclear and polymorphonuclear leukocytes generate gaps of similar micron-scale size when squeezing through inflamed endothelial barriers in vitro and Deodorants in vivo.To elucidate how leukocytes squeeze through these barriers, we co-tracked the endothelia

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Joining with Reactive Nano-Multilayers: Influence of Thermal Properties of Components on Joint Microstructure and Mechanical Performance

Reactive nano-multilayers (RNMLs), which are able to undergo a self-heating exothermal reaction, can, e.g., be utilised as a local heat source for soldering or brazing.Upon joining with RNMLs, the heat produced by the exothermal reaction must be carefully adjusted to the joining system in order to provide sufficient heat for bond formation while av

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Adventure Mode: A Speculative Rideshare Design

Most smart city projections presume efficiency, predictability, and control as core design principles for smart transportation.Adventure Mode is a speculative design proposal developed as part of a research project with a Anti-Perspirants major automotive company that proposes uses and interactions for Autonomous Vehicles (AVs) and rideshare advanc

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